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Peptide record

TPDB32799

Neurotoxin Toxicity standard
47 amino acids
Basic Information
3D PDB MODEL
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TPDB32799
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 47-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
KIKSGWERLTSESEYACPAIDKFCEDHCAAKKAVGKCDDFKCNCIKL
Physicochemical Analysis
C228H362N62O70S6
QM
K
5284.12
7.63
10
8
15
+1
14.79
-0.494
58.30
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
7365
139.38
12
Residue Composition
number
5
A
1
R
1
N
4
D
6
C
4
E
0
Q
2
G
1
H
3
I
2
L
8
K
0
M
2
F
1
P
3
S
1
T
1
W
1
Y
1
V
Amino Acid Distribution
A: 5 R: 1 N: 1 D: 4 C: 6 E: 4 Q: 0 G: 2 H: 1 I: 3 L: 2 K: 8 M: 0 F: 2 P: 1 S: 3 T: 1 W: 1 Y: 1 V: 1
Chemical Descriptors
47
C228H362N62O70S6
5284.12
7.63
+1
14.79
-0.494
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks voltage-gated potassium channels (By similarity). Its application (10 uM) to cells recombinantly expressing channels results in membrane damage and cell lysis (PubMed:36918120). {ECO:0000250|UniProtKB:P86822, ECO:0000269|PubMed:36918120}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Tityus costatus (Brazilian scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin
Blocks voltage-gated potassium channels (By similarity). Its application (10 uM) to cells recombinantly expressing channels results in membrane damage and cell lysis (PubMed:36918120)..
Potassium channel toxin TcoKIK
scorpion
Long chain scorpion toxin family, Class 2 subfamily
Evidence at protein level
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Membrane Neurotoxin Potassium channel impairing toxin Secreted Target cell membrane Target membrane Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:15683865, ECO:0000305|PubMed:17141373}.
Additional Detail Fields 7 fields
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Membrane Neurotoxin Potassium channel impairing toxin Secreted Target cell membrane Target membrane Toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin
Evidence at protein level
Long chain scorpion toxin family, Class 2 subfamily
Potassium channel toxin TcoKIK
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:15683865, ECO:0000305|PubMed:17141373}.
scorpion