Back to search

Peptide record

TPDB32739

Neurotoxin Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB32739
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 18-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
KECCTHPACHVSHPELCG
Physicochemical Analysis
C79H123N25O25S4
RNDQIMFWY
C
1951.24
6.29
4
2
3
-1
7.47
-0.322
43.33
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
250
12.81
6
Residue Composition
number
1
A
0
R
0
N
0
D
4
C
2
E
0
Q
1
G
3
H
0
I
1
L
1
K
0
M
0
F
2
P
1
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 4 E: 2 Q: 0 G: 1 H: 3 I: 0 L: 1 K: 1 M: 0 F: 0 P: 2 S: 1 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
18
C79H123N25O25S4
1951.24
6.29
-1
7.47
-0.322
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them (By similarity). Has possibly a distinct nAChR binding mode from other alpha-conotoxins, due to a different three residue motif (lacks the Ser-Xaa-Pro motif) (By similarity). {ECO:0000250|UniProtKB:Q2I2R8}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus bandanus (Banded marble cone)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them (By similarity). Has possibly a distinct nAChR binding mode from other alpha-conotoxins, due to a different three residue motif (lacks the Ser-Xaa-Pro motif) (By similarity)..
Alpha-conotoxin-like Bn1.2
cone snail
Conotoxin A superfamily
Evidence at transcript level
Acetylcholine receptor inhibiting toxin Amidation Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:14701840}.
Additional Detail Fields 7 fields
Acetylcholine receptor inhibiting toxin Amidation Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Evidence at transcript level
Conotoxin A superfamily
Alpha-conotoxin-like Bn1.2
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:14701840}.
cone snail