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Peptide record

TPDB32688

Neurotoxin Toxicity standard
30 amino acids
Basic Information
3D PDB MODEL
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TPDB32688
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 30-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
KEGYIVNYHTGCKYTCAKLGDNDYCLRECK
Physicochemical Analysis
C150H231N41O47S4
QMFPSW
CKY
3488.97
7.84
6
4
9
+1
7.13
-0.800
52.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
6210
177.99
12
Residue Composition
number
1
A
1
R
2
N
2
D
4
C
2
E
0
Q
3
G
1
H
1
I
2
L
4
K
0
M
0
F
0
P
0
S
2
T
0
W
4
Y
1
V
Amino Acid Distribution
A: 1 R: 1 N: 2 D: 2 C: 4 E: 2 Q: 0 G: 3 H: 1 I: 1 L: 2 K: 4 M: 0 F: 0 P: 0 S: 0 T: 2 W: 0 Y: 4 V: 1
Chemical Descriptors
30
C150H231N41O47S4
3488.97
7.84
+1
7.13
-0.800
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds to sodium channels (Nav) and inhibits the inactivation of the activated channels, thereby blocking neuronal transmission.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Centruroides tecomanus (Scorpion) (Centruroides limpidus tecomanus)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Binds to sodium channels (Nav) and inhibits the inactivation of the activated channels, thereby blocking neuronal transmission.
Neurotoxin II.22.5
scorpion
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Beta subfamily
Evidence at protein level
Direct protein sequencing Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:3201484}.
Additional Detail Fields 7 fields
Direct protein sequencing Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Beta subfamily
Neurotoxin II.22.5
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:3201484}.
scorpion