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Peptide record

TPDB32675

Neurotoxin Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB32675
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 14-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
KDGYPVDNANCKYE
Physicochemical Analysis
C69H102N18O25S1
RQHILMFSTW
NDKY
1615.73
4.31
2
3
4
-1
5.54
-1.529
27.86
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
2980
184.44
5
Residue Composition
number
1
A
0
R
2
N
2
D
1
C
1
E
0
Q
1
G
0
H
0
I
0
L
2
K
0
M
0
F
1
P
0
S
0
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 2 D: 2 C: 1 E: 1 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 2 V: 1
Chemical Descriptors
14
C69H102N18O25S1
1615.73
4.31
-1
5.54
-1.529
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds to sodium channels (Nav) and inhibits the inactivation of the activated channels, thereby blocking neuronal transmission (By similarity). Causes prolonged contractile paralysis in C.partellus larvae. It also has significant toxic effects on B.fusca larvae but not on mice. {ECO:0000250, ECO:0000269|PubMed:17618664}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Parabuthus liosoma (African black tail scorpion) (Parabuthus leiosoma)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Binds to sodium channels (Nav) and inhibits the inactivation of the activated channels, thereby blocking neuronal transmission (By similarity). Causes prolonged contractile paralysis in C.partellus larvae.
Insect toxin PlIT
scorpion
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family
Evidence at protein level
Direct protein sequencing Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Direct protein sequencing Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family
Insect toxin PlIT
TISSUE SPECIFICITY: Expressed by the venom gland.
scorpion