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Peptide record

TPDB32670

Neurotoxin Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB32670
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 29-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
KDGYLVGTDGCKYGCFTRPGHFCANEECL
Physicochemical Analysis
C137H203N37O43S4
QIMSW
G
3184.58
5.38
4
4
8
-1
5.13
-0.393
40.34
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
3230
101.43
9
Residue Composition
number
1
A
1
R
1
N
2
D
4
C
2
E
0
Q
5
G
1
H
0
I
2
L
2
K
0
M
2
F
1
P
0
S
2
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 1 R: 1 N: 1 D: 2 C: 4 E: 2 Q: 0 G: 5 H: 1 I: 0 L: 2 K: 2 M: 0 F: 2 P: 1 S: 0 T: 2 W: 0 Y: 2 V: 1
Chemical Descriptors
29
C137H203N37O43S4
3184.58
5.38
-1
5.13
-0.393
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds voltage-independently to sodium channels (Nav) and shifts the voltage of activation toward more negative potentials (By similarity). This toxin is active against mammals and also affects neuromuscular preparations of frog. {ECO:0000250}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Tityus discrepans (Venezuelan scorpion)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Binds voltage-independently to sodium channels (Nav) and shifts the voltage of activation toward more negative potentials (By similarity). This toxin is active against mammals and also affects neuromuscular preparations of frog..
Toxin TdII-3
scorpion
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Beta subfamily
Evidence at protein level
Direct protein sequencing Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Direct protein sequencing Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Beta subfamily
Toxin TdII-3
TISSUE SPECIFICITY: Expressed by the venom gland.
scorpion