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Peptide record

TPDB32657

Neurotoxin Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB32657
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 13-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
KDGYLPGNEGCKY
Physicochemical Analysis
C63H94N16O21S1
ARQHIMFSTWV
G
1443.59
6.35
2
2
3
-0
3.45
-1.338
30.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
2980
206.43
4
Residue Composition
number
0
A
0
R
1
N
1
D
1
C
1
E
0
Q
3
G
0
H
0
I
1
L
2
K
0
M
0
F
1
P
0
S
0
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 1 C: 1 E: 1 Q: 0 G: 3 H: 0 I: 0 L: 1 K: 2 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 2 V: 0
Chemical Descriptors
13
C63H94N16O21S1
1443.59
6.35
-0
3.45
-1.338
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing (By similarity). This toxin is active against mammals and crustaceans. {ECO:0000250}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Tityus discrepans (Venezuelan scorpion)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing (By similarity). This toxin is active against mammals and crustaceans..
Toxin TdII-2
scorpion
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Beta subfamily
Evidence at protein level
Direct protein sequencing Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Direct protein sequencing Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Beta subfamily
Toxin TdII-2
TISSUE SPECIFICITY: Expressed by the venom gland.
scorpion