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Peptide record

TPDB32496

Neurotoxin Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB32496
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 17-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
IVRRGCCSDPRCAWRCG
Physicochemical Analysis
C77H128N30O21S4
NEQHLKMFTY
RC
1938.29
8.75
4
1
4
+3
1.85
-0.300
45.88
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
5750
296.65
5
Residue Composition
number
1
A
4
R
0
N
1
D
4
C
0
E
0
Q
2
G
0
H
1
I
0
L
0
K
0
M
0
F
1
P
1
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 4 N: 0 D: 1 C: 4 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 1 S: 1 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
17
C77H128N30O21S4
1938.29
8.75
+3
1.85
-0.300
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks neuronal alpha-3-beta-2/CHRNA3-CHRNB2 (human and rat), alpha-7/CHRNA7 (human and rat), and alpha-3-beta-4/CHRNA3-CHRNB4 (human) nAChRs (PubMed:15609996, PubMed:19131337, PubMed:8206995). Acts voltage-independently (PubMed:15609996). Competes with alpha-bungarotoxin for binding to the receptor (PubMed:12384509, PubMed:15609996). Binds to a different site than alpha-conotoxin ImII (PubMed:15609996). Is highly active against the neuromuscular receptor in frog (PubMed:8206995). Also exhibits inhibition of D.melanogaster alpha-7 nAChRs (PubMed:25466886). {ECO:0000269|PubMed:12384509, ECO:0000269|PubMed:15609996, ECO:0000269|PubMed:19131337, ECO:0000269|PubMed:25466886, ECO:0000269|PubMed:8206995}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus imperialis (Imperial cone)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks neuronal alpha-3-beta-2/CHRNA3-CHRNB2 (human and rat), alpha-7/CHRNA7 (human and rat), and alpha-3-beta-4/CHRNA3-CHRNB4 (human) nAChRs (PubMed:15609996, PubMed:19131337, PubMed:8206995).
Alpha-conotoxin ImI (Alpha-CTx ImI)
cone snail
Conotoxin A superfamily
Evidence at protein level
3D-structure Acetylcholine receptor inhibiting toxin Amidation Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305}.
Additional Detail Fields 7 fields
3D-structure Acetylcholine receptor inhibiting toxin Amidation Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Evidence at protein level
Conotoxin A superfamily
Alpha-conotoxin ImI (Alpha-CTx ImI)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305}.
cone snail