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Peptide record

TPDB32479

Neurotoxin Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB32479
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 37-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
IVIDVPCTVSKECWSACKKAVGTDRGKCMGKKCKCYP
Physicochemical Analysis
C172H288N48O49S7
NQHLF
K
4036.89
8.87
8
3
11
+5
8.55
-0.151
57.84
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
7365
182.44
11
Residue Composition
number
2
A
1
R
0
N
2
D
6
C
1
E
0
Q
3
G
0
H
2
I
0
L
7
K
1
M
0
F
2
P
2
S
2
T
1
W
1
Y
4
V
Amino Acid Distribution
A: 2 R: 1 N: 0 D: 2 C: 6 E: 1 Q: 0 G: 3 H: 0 I: 2 L: 0 K: 7 M: 1 F: 0 P: 2 S: 2 T: 2 W: 1 Y: 1 V: 4
Chemical Descriptors
37
C172H288N48O49S7
4036.89
8.87
+5
8.55
-0.151
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks high conductance calcium-activated potassium channels. {ECO:0000250|UniProtKB:P0C182}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Rhopalurus junceus (Caribbean blue scorpion) (Heteroctenus junceus)
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Blocks high conductance calcium-activated potassium channels..
Potassium channel toxin alpha-KTx 1.18 (Peptide Rj1m1)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 01 subfamily
Evidence at protein level
Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:26169670}.
Additional Detail Fields 7 fields
Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 01 subfamily
Potassium channel toxin alpha-KTx 1.18 (Peptide Rj1m1)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:26169670}.
scorpion