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Peptide record

TPDB32452

Neurotoxin Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB32452
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 13-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
ITCCTRGTCAQHC
Physicochemical Analysis
C52H89N19O18S4
NDELKMFPSWYV
C
1396.64
7.85
2
0
2
+1
1.34
0.200
37.69
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
250
17.90
8
Residue Composition
number
1
A
1
R
0
N
0
D
4
C
0
E
1
Q
1
G
1
H
1
I
0
L
0
K
0
M
0
F
0
P
0
S
3
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 4 E: 0 Q: 1 G: 1 H: 1 I: 1 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 3 W: 0 Y: 0 V: 0
Chemical Descriptors
13
C52H89N19O18S4
1396.64
7.85
+1
1.34
0.200
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. {ECO:0000250}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus brunneus (Wood's brown cone)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them..
Alpha-conotoxin-like Br1.4
cone snail
Conotoxin A superfamily
Evidence at transcript level
Acetylcholine receptor inhibiting toxin Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 7 fields
Acetylcholine receptor inhibiting toxin Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Evidence at transcript level
Conotoxin A superfamily
Alpha-conotoxin-like Br1.4
TISSUE SPECIFICITY: Expressed by the venom duct.
cone snail