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Peptide record

TPDB32321

Neurotoxin Toxicity standard
39 amino acids
Basic Information
3D PDB MODEL
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TPDB32321
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 39-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
ILECVFSCDIKKEGKPCKPKGEKKCTGGWRCKIKLCLKI
Physicochemical Analysis
C195H333N53O50S6
ANQHMY
K
4412.47
9.52
11
4
10
+7
11.94
-0.341
77.44
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
5875
133.15
8
Residue Composition
number
0
A
1
R
0
N
1
D
6
C
3
E
0
Q
4
G
0
H
4
I
3
L
10
K
0
M
1
F
2
P
1
S
1
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 1 C: 6 E: 3 Q: 0 G: 4 H: 0 I: 4 L: 3 K: 10 M: 0 F: 1 P: 2 S: 1 T: 1 W: 1 Y: 0 V: 1
Chemical Descriptors
39
C195H333N53O50S6
4412.47
9.52
+7
11.94
-0.341
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits voltage-gated calcium channels (Cav) in rat cerebellar granule cells (By similarity). Has insecticidal activity to crickets (Acheta domesticus) (PubMed:19374957). Is not toxic to mice (PubMed:19374957). {ECO:0000250|UniProtKB:P0DL81, ECO:0000269|PubMed:19374957}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Brachypelma albiceps (Mexican golden redrump tarantula) (Brachypelma ruhnaui)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Inhibits voltage-gated calcium channels (Cav) in rat cerebellar granule cells (By similarity). Has insecticidal activity to crickets (Acheta domesticus) (PubMed:19374957).
Omega-theraphotoxin-Ba1a (Omega-TRTX-Ba1a) (Ba1)
spider
Neurotoxin 12 (Hwtx-2) family, 06 (TXP1) subfamily
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:19374957}.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Neurotoxin 12 (Hwtx-2) family, 06 (TXP1) subfamily
Omega-theraphotoxin-Ba1a (Omega-TRTX-Ba1a) (Ba1)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:19374957}.
spider