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Peptide record

TPDB32317

Neurotoxin Toxicity standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB32317
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 35-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
IKCTLSKDCYSPCKKETGCPRAKCINRNCKCYGCS
Physicochemical Analysis
C159H267N49O49S8
QHMFWV
C
3905.65
8.73
8
2
6
+6
8.09
-0.634
36.29
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
3480
89.10
17
Residue Composition
number
1
A
2
R
2
N
1
D
8
C
1
E
0
Q
2
G
0
H
2
I
1
L
6
K
0
M
0
F
2
P
3
S
2
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 1 R: 2 N: 2 D: 1 C: 8 E: 1 Q: 0 G: 2 H: 0 I: 2 L: 1 K: 6 M: 0 F: 0 P: 2 S: 3 T: 2 W: 0 Y: 2 V: 0
Chemical Descriptors
35
C159H267N49O49S8
3905.65
8.73
+6
8.09
-0.634
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks voltage-gated potassium channels rKv1.1/KCNA1 (IC(50)=13 nM), rKv1.2/KCNA2 (IC(50)=16 nM) and rKv1.3/KCNA3 (IC(50)=2 nM). {ECO:0000269|PubMed:18699777}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Hemiscorpius lepturus (Scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Blocks voltage-gated potassium channels rKv1.1/KCNA1 (IC(50)=13 nM), rKv1.2/KCNA2 (IC(50)=16 nM) and rKv1.3/KCNA3 (IC(50)=2 nM)..
Potassium channel toxin alpha-KTx 6.15 (Hemitoxin)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 06 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:18699777}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 06 subfamily
Potassium channel toxin alpha-KTx 6.15 (Hemitoxin)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:18699777}.
scorpion