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Peptide record

TPDB32274

Neurotoxin Toxicity standard
39 amino acids
Basic Information
3D PDB MODEL
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TPDB32274
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 39-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
IIECVFSCDIEKEGKPCKPKGEKKCSGGWKCKIKLCLKI
Physicochemical Analysis
C193H326N50O52S6
ARNQHMTY
K
4371.38
8.86
10
5
10
+5
13.39
-0.300
77.44
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
5875
134.40
8
Residue Composition
number
0
A
0
R
0
N
1
D
6
C
4
E
0
Q
4
G
0
H
5
I
2
L
10
K
0
M
1
F
2
P
2
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 1 C: 6 E: 4 Q: 0 G: 4 H: 0 I: 5 L: 2 K: 10 M: 0 F: 1 P: 2 S: 2 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
39
C193H326N50O52S6
4371.38
8.86
+5
13.39
-0.300
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits voltage-gated calcium channels (Cav) in rat cerebellar granule cells (By similarity). Has insecticidal activity (By similarity). {ECO:0000250|UniProtKB:P0DL63, ECO:0000250|UniProtKB:P85497}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Brachypelma smithi (Mexican red knee tarantula) (Eurypelma smithi)
Neurotoxin
Inhibits voltage-gated calcium channels (Cav) in rat cerebellar granule cells (By similarity). Has insecticidal activity (By similarity)..
Omega-theraphotoxin-Bs1b (Omega-TRTX-Bs1b) (BsTX1b) (Venom protein 1)
spider
Neurotoxin 12 (Hwtx-2) family, 06 (TXP1) subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:7801344}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Neurotoxin Secreted Toxin
Neurotoxin
Evidence at protein level
Neurotoxin 12 (Hwtx-2) family, 06 (TXP1) subfamily
Omega-theraphotoxin-Bs1b (Omega-TRTX-Bs1b) (BsTX1b) (Venom protein 1)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:7801344}.
spider