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Peptide record

TPDB32267

Neurotoxin Toxicity standard
38 amino acids
Basic Information
3D PDB MODEL
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TPDB32267
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 38-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
IFINVKCSSPQQCLKPCKKAFGQHAGGKCINGKCKCYP
Physicochemical Analysis
C180H292N52O47S6
RDEMTW
K
4128.98
9.54
8
0
10
+7
5.72
-0.305
53.95
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
1865
45.17
14
Residue Composition
number
2
A
0
R
2
N
0
D
6
C
0
E
3
Q
4
G
1
H
3
I
1
L
7
K
0
M
2
F
3
P
2
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 2 D: 0 C: 6 E: 0 Q: 3 G: 4 H: 1 I: 3 L: 1 K: 7 M: 0 F: 2 P: 3 S: 2 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
38
C180H292N52O47S6
4128.98
9.54
+7
5.72
-0.305
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks human voltage-gated potassium channels Kv1.2/KCNA2 (IC(50)=0.3 nM), Kv1.3/KCNA3 (IC(50)=8.3 nM) and Shaker IR (with inactivation domain removed) (IC(50)=12 nM) and blocks intermediate conductance calcium-activated potassium channel KCa3.1/KCNN4 (IC(50)=6.4 nM). {ECO:0000269|PubMed:26921461}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Centruroides tecomanus (Scorpion) (Centruroides limpidus tecomanus)
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Blocks human voltage-gated potassium channels Kv1.2/KCNA2 (IC(50)=0.3 nM), Kv1.3/KCNA3 (IC(50)=8.3 nM) and Shaker IR (with inactivation domain removed) (IC(50)=12 nM) and blocks intermediate conductance calcium-activated potassium channel KCa3.1/KCNN4 (IC(50)=6.4 nM)..
Potassium channel toxin alpha-KTx 2.15 (Toxin II.10.5)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 02 subfamily
Evidence at protein level
Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:26921461}.
Additional Detail Fields 7 fields
Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 02 subfamily
Potassium channel toxin alpha-KTx 2.15 (Toxin II.10.5)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:26921461}.
scorpion