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Peptide record

TPDB32266

Neurotoxin Toxicity standard
38 amino acids
Basic Information
3D PDB MODEL
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TPDB32266
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 38-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
IFINVKCSSPQQCLKPCKAAFGISAGGKCINGKCKCYP
Physicochemical Analysis
C175H286N48O47S6
RDEHMTW
CK
4006.85
9.22
6
0
12
+6
2.84
0.118
66.84
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
1865
46.55
14
Residue Composition
number
3
A
0
R
2
N
0
D
6
C
0
E
2
Q
4
G
0
H
4
I
1
L
6
K
0
M
2
F
3
P
3
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 3 R: 0 N: 2 D: 0 C: 6 E: 0 Q: 2 G: 4 H: 0 I: 4 L: 1 K: 6 M: 0 F: 2 P: 3 S: 3 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
38
C175H286N48O47S6
4006.85
9.22
+6
2.84
0.118
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Selective inhibitor of voltage-gated potassium channels, blocks the Kv1.2/KCNA2 (Kd=1.3 nM) and Kv1.3/KCNA3 (Kd=7.2 nM) channels. Association and dissociation rates of the toxin are slower for Kv1.2/KCNA2 than for Kv1.3/KCNA3. {ECO:0000269|PubMed:18786511}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Centruroides suffusus (Durango bark scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Selective inhibitor of voltage-gated potassium channels, blocks the Kv1.2/KCNA2 (Kd=1.3 nM) and Kv1.3/KCNA3 (Kd=7.2 nM) channels. Association and dissociation rates of the toxin are slower for Kv1.2/KCNA2 than for Kv1.3/KCNA3..
Potassium channel toxin alpha-KTx 2.13 (Toxin Css20)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 02 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:18786511}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 02 subfamily
Potassium channel toxin alpha-KTx 2.13 (Toxin Css20)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:18786511}.
scorpion