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Peptide record

TPDB32265

Neurotoxin Toxicity standard
38 amino acids
Basic Information
3D PDB MODEL
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TPDB32265
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 38-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
IFINVKCSLPQQCLRPCKDRFGQHAGGKCINGKCKCYP
Physicochemical Analysis
C184H298N56O48S6
EMTW
C
4255.10
9.24
8
1
10
+6
6.07
-0.355
61.58
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
1865
43.83
13
Residue Composition
number
1
A
2
R
2
N
1
D
6
C
0
E
3
Q
4
G
1
H
3
I
2
L
5
K
0
M
2
F
3
P
1
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 2 N: 2 D: 1 C: 6 E: 0 Q: 3 G: 4 H: 1 I: 3 L: 2 K: 5 M: 0 F: 2 P: 3 S: 1 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
38
C184H298N56O48S6
4255.10
9.24
+6
6.07
-0.355
Evidence Records 2 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks human voltage-gated potassium (Kv) channel Kv1.2/KCNA2 (Kd=0.376 nM) and Kv1.3/KCNA3 (Kd=126 nM). {ECO:0000269|PubMed:37624263}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Centruroides bonito (Scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Blocks human voltage-gated potassium (Kv) channel Kv1.2/KCNA2 (Kd=0.376 nM) and Kv1.3/KCNA3 (Kd=126 nM)..
Potassium channel toxin alpha-KTx 2.10 (CboK5)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 02 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:37624263}.
Evidence 2 Activity

Activity

Neurotoxin
FUNCTION: Weakly blocks Kv1.3/KCNA3 voltage-gated potassium channels (Kd is estimated to be 366 nM). {ECO:0000269|PubMed:16026809}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Centruroides elegans (Bark scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Weakly blocks Kv1.3/KCNA3 voltage-gated potassium channels (Kd is estimated to be 366 nM)..
Potassium channel toxin alpha-KTx 2.10 (Toxin Ce3)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 02 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:16026809}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 02 subfamily
Potassium channel toxin alpha-KTx 2.10 (CboK5) Potassium channel toxin alpha-KTx 2.10 (Toxin Ce3)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:37624263}. TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:16026809}.
scorpion