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Peptide record

TPDB32255

Neurotoxin Toxicity standard
39 amino acids
Basic Information
3D PDB MODEL
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TPDB32255
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 39-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
IFECVFSCDIEKEGKPCKPKGEKKCSGGWKCKIKLCLKI
Physicochemical Analysis
C196H324N50O52S6
ARNQHMTY
K
4405.39
8.86
10
5
10
+5
12.57
-0.344
67.44
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
5875
133.36
8
Residue Composition
number
0
A
0
R
0
N
1
D
6
C
4
E
0
Q
4
G
0
H
4
I
2
L
10
K
0
M
2
F
2
P
2
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 1 C: 6 E: 4 Q: 0 G: 4 H: 0 I: 4 L: 2 K: 10 M: 0 F: 2 P: 2 S: 2 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
39
C196H324N50O52S6
4405.39
8.86
+5
12.57
-0.344
Evidence Records 2 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits voltage-gated calcium channels (Cav) in rat cerebellar granule cells (By similarity). Has insecticidal activity (By similarity). {ECO:0000250|UniProtKB:P0DL63, ECO:0000250|UniProtKB:P85497}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Brachypelma smithi (Mexican red knee tarantula) (Eurypelma smithi)
Neurotoxin
Inhibits voltage-gated calcium channels (Cav) in rat cerebellar granule cells (By similarity). Has insecticidal activity (By similarity)..
Omega-theraphotoxin-Bs1a (Omega-TRTX-Bs1a) (BsTX1a) (Venom protein 1)
spider
Neurotoxin 12 (Hwtx-2) family, 06 (TXP1) subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:7801344}.
Evidence 2 Activity

Activity

Neurotoxin
FUNCTION: Inhibits voltage-gated calcium channels (Cav) in rat cerebellar granule cells (By similarity). Has insecticidal activity (By similarity). {ECO:0000250|UniProtKB:P0DL81, ECO:0000250|UniProtKB:P61509}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Aphonopelma sp. (American tarantula)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Inhibits voltage-gated calcium channels (Cav) in rat cerebellar granule cells (By similarity). Has insecticidal activity (By similarity)..
Omega-theraphotoxin-Asp1g (Omega-TRTX-Asp1g) (Eurypelma spider toxin 2) (ESTx2)
spider
Neurotoxin 12 (Hwtx-2) family, 06 (TXP1) subfamily
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:2742756}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Neurotoxin Secreted Toxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Neurotoxin 12 (Hwtx-2) family, 06 (TXP1) subfamily
Omega-theraphotoxin-Bs1a (Omega-TRTX-Bs1a) (BsTX1a) (Venom protein 1) Omega-theraphotoxin-Asp1g (Omega-TRTX-Asp1g) (Eurypelma spider toxin 2) (ESTx2)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:7801344}. TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:2742756}.
spider