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Peptide record

TPDB32217

Neurotoxin Toxicity standard
36 amino acids
Basic Information
3D PDB MODEL
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TPDB32217
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 36-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
IACAPRGQLCFSDKLCCIGLRCKSRVANMWPTFCLV
Physicochemical Analysis
C174H284N50O44S7
EHY
C
4004.90
8.60
5
1
15
+4
-1.05
0.597
89.44
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
5875
146.70
11
Residue Composition
number
3
A
3
R
1
N
1
D
6
C
0
E
1
Q
2
G
0
H
2
I
4
L
2
K
1
M
2
F
2
P
2
S
1
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 3 R: 3 N: 1 D: 1 C: 6 E: 0 Q: 1 G: 2 H: 0 I: 2 L: 4 K: 2 M: 1 F: 2 P: 2 S: 2 T: 1 W: 1 Y: 0 V: 2
Chemical Descriptors
36
C174H284N50O44S7
4004.90
8.60
+4
-1.05
0.597
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Neurotoxin. Causes spastic paralysis and death in mice. Does not inhibit L-type calcium channels. {ECO:0000269|Ref.2}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Phoneutria keyserlingi (Brazilian wandering spider) (Ctenus keyserlingii)
Neurotoxin
Neurotoxin. Causes spastic paralysis and death in mice.
U6-ctenitoxin-Pk1a (U6-CNTX-Pk1a) (Neurotoxin PKTx32C4)
spider
Neurotoxin 10 (Hwtx-1) family, 53 (PNTx27C4) subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Knottin Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:16278100, ECO:0000269|Ref.2, ECO:0000305}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Knottin Neurotoxin Secreted Toxin
Neurotoxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family, 53 (PNTx27C4) subfamily
U6-ctenitoxin-Pk1a (U6-CNTX-Pk1a) (Neurotoxin PKTx32C4)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:16278100, ECO:0000269|Ref.2, ECO:0000305}.
spider