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Peptide record

TPDB32216

Neurotoxin Toxicity standard
36 amino acids
Basic Information
3D PDB MODEL
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TPDB32216
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 36-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
IACAPRGLLCFRDKECCKGLTCKGRFVNTWPTFCLV
Physicochemical Analysis
C179H286N50O45S6
QHMSY
C
4050.91
8.60
6
2
13
+4
0.99
0.333
75.83
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
5875
145.03
10
Residue Composition
number
2
A
3
R
1
N
1
D
6
C
1
E
0
Q
3
G
0
H
1
I
4
L
3
K
0
M
3
F
2
P
0
S
3
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 3 N: 1 D: 1 C: 6 E: 1 Q: 0 G: 3 H: 0 I: 1 L: 4 K: 3 M: 0 F: 3 P: 2 S: 0 T: 3 W: 1 Y: 0 V: 2
Chemical Descriptors
36
C179H286N50O45S6
4050.91
8.60
+4
0.99
0.333
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Neurotoxin. Causes spastic paralysis and death in mice. Moderate inhibitor of L-type calcium channels (Cav1/CACNA1). {ECO:0000269|Ref.2}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Phoneutria reidyi (Brazilian Amazonian armed spider) (Ctenus reidyi)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Neurotoxin. Causes spastic paralysis and death in mice.
U4-ctenitoxin-Pr1a (U4-CNTX-Pr1a) (Neurotoxin PRTx27C3)
spider
Neurotoxin 10 (Hwtx-1) family, 53 (PNTx27C4) subfamily
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:16278100, ECO:0000269|Ref.2, ECO:0000305}.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family, 53 (PNTx27C4) subfamily
U4-ctenitoxin-Pr1a (U4-CNTX-Pr1a) (Neurotoxin PRTx27C3)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:16278100, ECO:0000269|Ref.2, ECO:0000305}.
spider