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Peptide record

TPDB32215

Neurotoxin Toxicity standard
36 amino acids
Basic Information
3D PDB MODEL
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TPDB32215
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 36-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
IACAPRFSLCNSDKECCKGLRCQSRIANMWPTFCSQ
Physicochemical Analysis
C170H272N52O50S7
HYV
C
4068.77
8.31
5
2
11
+3
3.20
-0.172
51.67
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
5875
144.39
15
Residue Composition
number
3
A
3
R
2
N
1
D
6
C
1
E
2
Q
1
G
0
H
2
I
2
L
2
K
1
M
2
F
2
P
4
S
1
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 3 N: 2 D: 1 C: 6 E: 1 Q: 2 G: 1 H: 0 I: 2 L: 2 K: 2 M: 1 F: 2 P: 2 S: 4 T: 1 W: 1 Y: 0 V: 0
Chemical Descriptors
36
C170H272N52O50S7
4068.77
8.31
+3
3.20
-0.172
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Neurotoxin. Causes spastic paralysis and death in mice. Moderate inhibitor of L-type calcium channels (Cav1/CACNA1). {ECO:0000269|Ref.2}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Phoneutria nigriventer (Brazilian armed spider) (Ctenus nigriventer)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Neurotoxin. Causes spastic paralysis and death in mice.
U17-ctenitoxin-Pn1a (U17-CNTX-Pn1a) (Neurotoxin PNTx27C4)
spider
Neurotoxin 10 (Hwtx-1) family, 53 (PNTx27C4) subfamily
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:16278100, ECO:0000269|Ref.2}.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family, 53 (PNTx27C4) subfamily
U17-ctenitoxin-Pn1a (U17-CNTX-Pn1a) (Neurotoxin PNTx27C4)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:16278100, ECO:0000269|Ref.2}.
spider