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Peptide record

TPDB32172

Neurotoxin Toxicity standard
34 amino acids
Basic Information
3D PDB MODEL
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TPDB32172
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 34-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
HLLQFNKVIKFETRKNAIPFYAFYGCYCGWGGRG
Physicochemical Analysis
C188H271N49O44S2
DMS
G
3985.64
9.78
6
1
15
+4
-2.05
-0.188
60.29
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
10095
253.28
9
Residue Composition
number
2
A
2
R
2
N
0
D
2
C
1
E
1
Q
5
G
1
H
2
I
2
L
3
K
0
M
4
F
1
P
0
S
1
T
1
W
3
Y
1
V
Amino Acid Distribution
A: 2 R: 2 N: 2 D: 0 C: 2 E: 1 Q: 1 G: 5 H: 1 I: 2 L: 2 K: 3 M: 0 F: 4 P: 1 S: 0 T: 1 W: 1 Y: 3 V: 1
Chemical Descriptors
34
C188H271N49O44S2
3985.64
9.78
+4
-2.05
-0.188
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Snake venom phospholipase A2 (PLA2) that inhibits neuromuscular transmission by blocking acetylcholine release from the nerve termini. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (By similarity). {ECO:0000250}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Micrurus pyrrhocryptus (Coral snake)
Neurotoxin Presynaptic neurotoxin
Snake venom phospholipase A2 (PLA2) that inhibits neuromuscular transmission by blocking acetylcholine release from the nerve termini. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (By similarity)..
Phospholipase A2 B1 (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase)
snake
Phospholipase A2 family, Group II subfamily
Evidence at protein level
Calcium Direct protein sequencing Disulfide bond Hydrolase Lipid degradation Lipid metabolism Metal-binding Neurotoxin Presynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Calcium Direct protein sequencing Disulfide bond Hydrolase Lipid degradation Lipid metabolism Metal-binding Neurotoxin Presynaptic neurotoxin Secreted Toxin
Neurotoxin Presynaptic neurotoxin
Evidence at protein level
Phospholipase A2 family, Group II subfamily
Phospholipase A2 B1 (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase)
TISSUE SPECIFICITY: Expressed by the venom gland.
snake