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Peptide record

TPDB32170

Neurotoxin Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB32170
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 23-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
HLLQFNKMIKFETRKNAIPFYAF
Physicochemical Analysis
C137H206N34O31S1
DCGSWV
F
2857.41
10.46
5
1
12
+3
1.00
-0.161
76.52
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
1490
52.15
5
Residue Composition
number
2
A
1
R
2
N
0
D
0
C
1
E
1
Q
0
G
1
H
2
I
2
L
3
K
1
M
4
F
1
P
0
S
1
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 2 R: 1 N: 2 D: 0 C: 0 E: 1 Q: 1 G: 0 H: 1 I: 2 L: 2 K: 3 M: 1 F: 4 P: 1 S: 0 T: 1 W: 0 Y: 1 V: 0
Chemical Descriptors
23
C137H206N34O31S1
2857.41
10.46
+3
1.00
-0.161
Evidence Records 3 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Snake venom phospholipase A2 (PLA2) that shows presynaptic neurotoxicity. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. {ECO:0000269|PubMed:15032748}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Crotalus basiliscus (Mexican west-coast rattlesnake)
Neurotoxin Presynaptic neurotoxin
Snake venom phospholipase A2 (PLA2) that shows presynaptic neurotoxicity. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides..
Basic phospholipase A2 CB1 (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase)
snake
Phospholipase A2 family, Group II subfamily
Evidence at protein level
Calcium Direct protein sequencing Disulfide bond Hydrolase Lipid degradation Lipid metabolism Metal-binding Neurotoxin Presynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Evidence 2 Activity

Activity

Neurotoxin
FUNCTION: Snake venom phospholipase A2 (PLA2) that shows presynaptic neurotoxicity. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. {ECO:0000269|PubMed:15032748}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Crotalus vegrandis (Uracoan rattlesnake) (Crotalus durissus vegrandis)
Neurotoxin Presynaptic neurotoxin
Snake venom phospholipase A2 (PLA2) that shows presynaptic neurotoxicity. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides..
Basic phospholipase A2 CB1 (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase)
snake
Phospholipase A2 family, Group II subfamily
Evidence at protein level
Calcium Direct protein sequencing Disulfide bond Hydrolase Lipid degradation Lipid metabolism Metal-binding Neurotoxin Presynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Evidence 3 Activity

Activity

Neurotoxin
FUNCTION: Snake venom phospholipase A2 (PLA2) that shows presynaptic neurotoxicity. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. {ECO:0000269|PubMed:15032748}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Crotalus durissus cumanensis (South American rattlesnake)
Neurotoxin Presynaptic neurotoxin
Snake venom phospholipase A2 (PLA2) that shows presynaptic neurotoxicity. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides..
Basic phospholipase A2 CB1 (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase)
snake
Phospholipase A2 family, Group II subfamily
Evidence at protein level
Calcium Direct protein sequencing Disulfide bond Hydrolase Lipid degradation Lipid metabolism Metal-binding Neurotoxin Presynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Calcium Direct protein sequencing Disulfide bond Hydrolase Lipid degradation Lipid metabolism Metal-binding Neurotoxin Presynaptic neurotoxin Secreted Toxin
Neurotoxin Presynaptic neurotoxin
Evidence at protein level
Phospholipase A2 family, Group II subfamily
Basic phospholipase A2 CB1 (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase)
TISSUE SPECIFICITY: Expressed by the venom gland.
snake