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Peptide record

TPDB32145

Neurotoxin Toxicity standard
36 amino acids
Basic Information
3D PDB MODEL
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TPDB32145
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 36-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
HFIDVKCTTSKECWPPCKAATGKAAGKCMNKKCKCQ
Physicochemical Analysis
C167H275N49O47S7
RLY
K
3945.74
9.23
9
2
9
+6
9.03
-0.572
30.00
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
5875
148.89
12
Residue Composition
number
4
A
0
R
1
N
1
D
6
C
1
E
1
Q
2
G
1
H
1
I
0
L
8
K
1
M
1
F
2
P
1
S
3
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 4 R: 0 N: 1 D: 1 C: 6 E: 1 Q: 1 G: 2 H: 1 I: 1 L: 0 K: 8 M: 1 F: 1 P: 2 S: 1 T: 3 W: 1 Y: 0 V: 1
Chemical Descriptors
36
C167H275N49O47S7
3945.74
9.23
+6
9.03
-0.572
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Potent selective inhibitor of Kv1/KCNA voltage-gated potassium channels. {ECO:0000250}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Centruroides limbatus (Bark scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Potent selective inhibitor of Kv1/KCNA voltage-gated potassium channels..
Potassium channel toxin alpha-KTx 1.9 (Hongotoxin-2) (HgTX2)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 01 subfamily
Evidence at protein level
Direct protein sequencing Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Direct protein sequencing Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 01 subfamily
Potassium channel toxin alpha-KTx 1.9 (Hongotoxin-2) (HgTX2)
TISSUE SPECIFICITY: Expressed by the venom gland.
scorpion