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Peptide record

TPDB32073

Neurotoxin Toxicity standard
49 amino acids
Basic Information
3D PDB MODEL
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TPDB32073
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 49-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
GVSCLCDSDGPSVRGNTLSGILWFYPSGCPSGWHNCKAHGPTIGWCCKQ
Physicochemical Analysis
C225H334N64O66S6
EM
G
5183.88
7.65
5
2
13
+1
0.14
-0.155
53.67
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
18365
354.27
18
Residue Composition
number
1
A
1
R
2
N
2
D
6
C
0
E
1
Q
8
G
2
H
2
I
3
L
2
K
0
M
1
F
4
P
6
S
2
T
3
W
1
Y
2
V
Amino Acid Distribution
A: 1 R: 1 N: 2 D: 2 C: 6 E: 0 Q: 1 G: 8 H: 2 I: 2 L: 3 K: 2 M: 0 F: 1 P: 4 S: 6 T: 2 W: 3 Y: 1 V: 2
Chemical Descriptors
49
C225H334N64O66S6
5183.88
7.65
+1
0.14
-0.155
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds specifically to voltage-gated sodium channels (Nav) (site 3), thereby delaying their inactivation during signal transduction. Thus it may strongly stimulate mammalian cardiac muscle contraction. {ECO:0000269|PubMed:9604281}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Anthopleura xanthogrammica (Giant green sea anemone) (Actinia xanthogrammica)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Binds specifically to voltage-gated sodium channels (Nav) (site 3), thereby delaying their inactivation during signal transduction. Thus it may strongly stimulate mammalian cardiac muscle contraction..
Delta-actitoxin-Axm1h (Delta-AITX-Axm1h) (PCR3-7) (Toxin PCR6)
sea anemone
Sea anemone sodium channel inhibitory toxin family, Type I subfamily
Evidence at transcript level
Cardiotoxin Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Additional Detail Fields 6 fields
Cardiotoxin Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at transcript level
Sea anemone sodium channel inhibitory toxin family, Type I subfamily
Delta-actitoxin-Axm1h (Delta-AITX-Axm1h) (PCR3-7) (Toxin PCR6)
sea anemone