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Peptide record

TPDB32065

Neurotoxin Toxicity standard
38 amino acids
Basic Information
3D PDB MODEL
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TPDB32065
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 38-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
GVPTDVKCRGSPQCIQPCKDAGMRFGKCMNGKCHCTPK
Physicochemical Analysis
C167H278N54O49S8
ELWY
C
4082.86
8.90
8
2
7
+5
10.46
-0.618
28.16
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
375
9.18
12
Residue Composition
number
1
A
2
R
1
N
2
D
6
C
0
E
2
Q
5
G
1
H
1
I
0
L
5
K
2
M
1
F
4
P
1
S
2
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 2 N: 1 D: 2 C: 6 E: 0 Q: 2 G: 5 H: 1 I: 1 L: 0 K: 5 M: 2 F: 1 P: 4 S: 1 T: 2 W: 0 Y: 0 V: 2
Chemical Descriptors
38
C167H278N54O49S8
4082.86
8.90
+5
10.46
-0.618
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks the voltage-gated potassium channel Kv1.3/KCNA3 (IC(50)=7.2 nM) (PubMed:18471844, PubMed:29483648). Correnti and colleagues have also shown that this toxin inhibits Kv1.1/KCNA1, which is different from Abdel-Mottaleb and colleagues conclusions (PubMed:29483648). {ECO:0000269|PubMed:18471844, ECO:0000269|PubMed:29483648}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Odontobuthus doriae (Yellow Iranian scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Blocks the voltage-gated potassium channel Kv1.3/KCNA3 (IC(50)=7.2 nM) (PubMed:18471844, PubMed:29483648). Correnti and colleagues have also shown that this toxin inhibits Kv1.1/KCNA1, which is different from Abdel-Mottaleb and colleagues conclusions (PubMed:29483648)..
Potassium channel toxin alpha-KTx 3.11 (OdK2)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 03 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:18471844}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 03 subfamily
Potassium channel toxin alpha-KTx 3.11 (OdK2)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:18471844}.
scorpion