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Peptide record

TPDB32063

Neurotoxin Toxicity standard
38 amino acids
Basic Information
3D PDB MODEL
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TPDB32063
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 38-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
GVPINVPCTGSPQCIKPCKDAGMRFGKCMNRKCHCTPK
Physicochemical Analysis
C171H286N54O47S8
ELWY
C
4106.97
9.30
8
1
8
+6
9.20
-0.439
38.42
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
375
9.13
12
Residue Composition
number
1
A
2
R
2
N
1
D
6
C
0
E
1
Q
4
G
1
H
2
I
0
L
5
K
2
M
1
F
5
P
1
S
2
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 2 N: 2 D: 1 C: 6 E: 0 Q: 1 G: 4 H: 1 I: 2 L: 0 K: 5 M: 2 F: 1 P: 5 S: 1 T: 2 W: 0 Y: 0 V: 2
Chemical Descriptors
38
C171H286N54O47S8
4106.97
9.30
+6
9.20
-0.439
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Potent inhibitor of shaker potassium channels as well as the mammalian homologs of shaker.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Leiurus hebraeus (Hebrew deathstalker scorpion) (Leiurus quinquestriatus hebraeus)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin
Potent inhibitor of shaker potassium channels as well as the mammalian homologs of shaker.
Potassium channel toxin alpha-KTx 3.3 (Agitoxin-3) (AgTx-3) (AgTx3)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 03 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 03 subfamily
Potassium channel toxin alpha-KTx 3.3 (Agitoxin-3) (AgTx-3) (AgTx3)
TISSUE SPECIFICITY: Expressed by the venom gland.
scorpion