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Peptide record

TPDB32062

Neurotoxin Toxicity standard
38 amino acids
Basic Information
3D PDB MODEL
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TPDB32062
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 38-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
GVPINVKCTGSPQCLKPCKDAGMRFGKCINGKCHCTPK
Physicochemical Analysis
C169H284N52O47S7
EWY
CK
4020.85
9.27
8
1
8
+6
8.61
-0.342
48.68
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
375
9.33
12
Residue Composition
number
1
A
1
R
2
N
1
D
6
C
0
E
1
Q
5
G
1
H
2
I
1
L
6
K
1
M
1
F
4
P
1
S
2
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 1 N: 2 D: 1 C: 6 E: 0 Q: 1 G: 5 H: 1 I: 2 L: 1 K: 6 M: 1 F: 1 P: 4 S: 1 T: 2 W: 0 Y: 0 V: 2
Chemical Descriptors
38
C169H284N52O47S7
4020.85
9.27
+6
8.61
-0.342
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Potent inhibitor of the Shaker potassium channel (Ki=0.16 nM) and its mammalian homologs (Kv1.3/KCNA3 (Ki=1.7 nM), Kv1.1/KCNA1 (Ki=136 nM), Kv1.6/KCNA6 (Ki=149 nM)). {ECO:0000269|PubMed:8204618}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Leiurus hebraeus (Hebrew deathstalker scorpion) (Leiurus quinquestriatus hebraeus)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Potent inhibitor of the Shaker potassium channel (Ki=0.16 nM) and its mammalian homologs (Kv1.3/KCNA3 (Ki=1.7 nM), Kv1.1/KCNA1 (Ki=136 nM), Kv1.6/KCNA6 (Ki=149 nM))..
Potassium channel toxin alpha-KTx 3.4 (Agitoxin-1) (AgTx-1) (AgTx1) (Leiurotoxin II) (LeTx II) (Leiurotoxin-2)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 03 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:8204618}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 03 subfamily
Potassium channel toxin alpha-KTx 3.4 (Agitoxin-1) (AgTx-1) (AgTx1) (Leiurotoxin II) (LeTx II) (Leiurotoxin-2)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:8204618}.
scorpion