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Peptide record

TPDB32061

Neurotoxin Toxicity standard
38 amino acids
Basic Information
3D PDB MODEL
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TPDB32061
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 38-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
GVPINVKCSGSRDCLEPCKKAGMRFGKCINRKCHCTPK
Physicochemical Analysis
C173H295N57O48S7
QWY
CK
4166.02
9.67
10
2
8
+7
11.20
-0.529
48.68
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
375
9.00
11
Residue Composition
number
1
A
3
R
2
N
1
D
6
C
1
E
0
Q
4
G
1
H
2
I
1
L
6
K
1
M
1
F
3
P
2
S
1
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 3 N: 2 D: 1 C: 6 E: 1 Q: 0 G: 4 H: 1 I: 2 L: 1 K: 6 M: 1 F: 1 P: 3 S: 2 T: 1 W: 0 Y: 0 V: 2
Chemical Descriptors
38
C173H295N57O48S7
4166.02
9.67
+7
11.20
-0.529
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Completely inhibits the (125)I-kaliotoxin binding on rat brain synaptosomes with high-affinity (IC(50)=0.1 nM). Is a potent Kv1.3/KCNA3 ligand. {ECO:0000269|PubMed:23523531}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Buthus paris (Scorpion) (Buthus occitanus paris)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Completely inhibits the (125)I-kaliotoxin binding on rat brain synaptosomes with high-affinity (IC(50)=0.1 nM). Is a potent Kv1.3/KCNA3 ligand..
Potassium channel toxin alpha-KTx 3.17 (Toxin BoPKTX)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 03 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 03 subfamily
Potassium channel toxin alpha-KTx 3.17 (Toxin BoPKTX)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
scorpion