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Peptide record

TPDB32059

Neurotoxin Toxicity standard
38 amino acids
Basic Information
3D PDB MODEL
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TPDB32059
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 38-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
GVPINVKCRGSPQCIQPCRDAGMRFGKCMNGKCHCTPQ
Physicochemical Analysis
C168H279N57O48S8
ELWY
C
4121.90
8.92
7
1
8
+5
8.61
-0.487
38.42
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
375
9.10
13
Residue Composition
number
1
A
3
R
2
N
1
D
6
C
0
E
3
Q
5
G
1
H
2
I
0
L
3
K
2
M
1
F
4
P
1
S
1
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 3 N: 2 D: 1 C: 6 E: 0 Q: 3 G: 5 H: 1 I: 2 L: 0 K: 3 M: 2 F: 1 P: 4 S: 1 T: 1 W: 0 Y: 0 V: 2
Chemical Descriptors
38
C168H279N57O48S8
4121.90
8.92
+5
8.61
-0.487
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Potassium channel inhibitor. {ECO:0000250}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Hottentotta tamulus sindicus (Scorpion) (Buthus sindicus)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin
Potassium channel inhibitor..
Potassium channel toxin alpha-KTx 3.8 (Charybdotoxin-like peptide Bs 6) (Bs6)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 03 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:10048185}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 03 subfamily
Potassium channel toxin alpha-KTx 3.8 (Charybdotoxin-like peptide Bs 6) (Bs6)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:10048185}.
scorpion