Back to search

Peptide record

TPDB32054

Neurotoxin Toxicity standard
47 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB32054
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 47-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
GVPCRCDSDGPSVHGNTLSGTIWVGSCETGWHKCNTEHNLFHECCKQ
Physicochemical Analysis
C214H322N66O70S6
AMY
CG
5131.67
6.02
7
5
9
-2
11.54
-0.585
43.40
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
11375
221.66
18
Residue Composition
number
0
A
1
R
3
N
2
D
6
C
3
E
1
Q
6
G
4
H
1
I
2
L
2
K
0
M
1
F
2
P
4
S
4
T
2
W
0
Y
3
V
Amino Acid Distribution
A: 0 R: 1 N: 3 D: 2 C: 6 E: 3 Q: 1 G: 6 H: 4 I: 1 L: 2 K: 2 M: 0 F: 1 P: 2 S: 4 T: 4 W: 2 Y: 0 V: 3
Chemical Descriptors
47
C214H322N66O70S6
5131.67
6.02
-2
11.54
-0.585
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits voltage-gated sodium channels (Nav). {ECO:0000250|UniProtKB:P0C280}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Radianthus crispa (Leathery sea anemone) (Heteractis crispa)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Inhibits voltage-gated sodium channels (Nav)..
Delta-stichotoxin-Hcr3a (Delta-SHTX-Hcr3a) (Rc-I) (Rc I) (Rc-1)
sea anemone
Sea anemone sodium channel inhibitory toxin family, Type I subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Additional Detail Fields 6 fields
Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Sea anemone sodium channel inhibitory toxin family, Type I subfamily
Delta-stichotoxin-Hcr3a (Delta-SHTX-Hcr3a) (Rc-I) (Rc I) (Rc-1)
sea anemone