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Peptide record

TPDB32050

Neurotoxin Toxicity standard
47 amino acids
Basic Information
3D PDB MODEL
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TPDB32050
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 47-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
GVPCLCDSDGPSVRGNTLSGTLWLAGCPSGWHNCKAHGPTIGWCCKK
Physicochemical Analysis
C209H322N62O61S6
EQMFY
G
4871.59
8.02
6
2
12
+2
2.08
-0.160
58.09
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
16875
346.40
15
Residue Composition
number
2
A
1
R
2
N
2
D
6
C
0
E
0
Q
8
G
2
H
1
I
4
L
3
K
0
M
0
F
4
P
4
S
3
T
3
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 1 N: 2 D: 2 C: 6 E: 0 Q: 0 G: 8 H: 2 I: 1 L: 4 K: 3 M: 0 F: 0 P: 4 S: 4 T: 3 W: 3 Y: 0 V: 2
Chemical Descriptors
47
C209H322N62O61S6
4871.59
8.02
+2
2.08
-0.160
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds specifically to voltage-gated sodium channels (Nav) (site 3), thereby delaying their inactivation during signal transduction (By similarity). Has a heart stimulation effect on isolated rat atria that is higher than that of Hk7a, Hk8a and Hk16a (PubMed:12782079, PubMed:14672713). {ECO:0000250, ECO:0000269|PubMed:12782079, ECO:0000269|PubMed:14672713}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Anthopleura sp. (strain 'Zhanjiang') (Sea anemone)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Binds specifically to voltage-gated sodium channels (Nav) (site 3), thereby delaying their inactivation during signal transduction (By similarity). Has a heart stimulation effect on isolated rat atria that is higher than that of Hk7a, Hk8a and Hk16a (PubMed:12782079, PubMed:14672713)..
Delta-actitoxin-Aspp1a (Delta-AITX-Aspp1a) (Toxin Hk2a)
sea anemone
Sea anemone sodium channel inhibitory toxin family, Type I subfamily
Evidence at transcript level
Cardiotoxin Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Additional Detail Fields 6 fields
Cardiotoxin Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at transcript level
Sea anemone sodium channel inhibitory toxin family, Type I subfamily
Delta-actitoxin-Aspp1a (Delta-AITX-Aspp1a) (Toxin Hk2a)
sea anemone