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Peptide record

TPDB32049

Neurotoxin Toxicity standard
46 amino acids
Basic Information
3D PDB MODEL
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TPDB32049
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 46-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
GVPCLCDSDGPSVRGNTLSGILWLAGCPSGWHNCKKHKPTIGWCCK
Physicochemical Analysis
C212H330N62O59S6
EQMFY
G
4883.69
8.31
7
2
12
+3
2.78
-0.165
65.65
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
16875
345.54
14
Residue Composition
number
1
A
1
R
2
N
2
D
6
C
0
E
0
Q
7
G
2
H
2
I
4
L
4
K
0
M
0
F
4
P
4
S
2
T
3
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 1 N: 2 D: 2 C: 6 E: 0 Q: 0 G: 7 H: 2 I: 2 L: 4 K: 4 M: 0 F: 0 P: 4 S: 4 T: 2 W: 3 Y: 0 V: 2
Chemical Descriptors
46
C212H330N62O59S6
4883.69
8.31
+3
2.78
-0.165
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds specifically to voltage-gated sodium channels (Nav), thereby delaying their inactivation during signal transduction. Thus it strongly stimulates mammalian cardiac muscle contraction. {ECO:0000269|PubMed:6127075}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Anemonia sulcata (Mediterranean snakelocks sea anemone)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Binds specifically to voltage-gated sodium channels (Nav), thereby delaying their inactivation during signal transduction. Thus it strongly stimulates mammalian cardiac muscle contraction..
Delta-actitoxin-Avd1d (Delta-AITX-Avd1d) (ATX-V) (As5) (Toxin V)
sea anemone
Sea anemone sodium channel inhibitory toxin family, Type I subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Additional Detail Fields 6 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Sea anemone sodium channel inhibitory toxin family, Type I subfamily
Delta-actitoxin-Avd1d (Delta-AITX-Avd1d) (ATX-V) (As5) (Toxin V)
sea anemone