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Peptide record

TPDB32031

Neurotoxin Toxicity standard
47 amino acids
Basic Information
3D PDB MODEL
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TPDB32031
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 47-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
GVPCLCDSDGPNVRGNTLSGTYWLAGCPSGWHNCKSSGPNIGWCCKK
Physicochemical Analysis
C210H318N62O64S6
EQMF
G
4927.57
8.02
5
2
11
+2
1.74
-0.389
47.66
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
18365
372.70
18
Residue Composition
number
1
A
1
R
4
N
2
D
6
C
0
E
0
Q
8
G
1
H
1
I
3
L
3
K
0
M
0
F
4
P
5
S
2
T
3
W
1
Y
2
V
Amino Acid Distribution
A: 1 R: 1 N: 4 D: 2 C: 6 E: 0 Q: 0 G: 8 H: 1 I: 1 L: 3 K: 3 M: 0 F: 0 P: 4 S: 5 T: 2 W: 3 Y: 1 V: 2
Chemical Descriptors
47
C210H318N62O64S6
4927.57
8.02
+2
1.74
-0.389
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Weakly inhibits voltage-gated sodium channels (Nav). {ECO:0000269|PubMed:9604281}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Anthopleura xanthogrammica (Giant green sea anemone) (Actinia xanthogrammica)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Weakly inhibits voltage-gated sodium channels (Nav)..
Delta-actitoxin-Axm1c (Delta-AITX-Axm1c) (PCR1-2) (Toxin PCR1)
sea anemone
Sea anemone sodium channel inhibitory toxin family, Type I subfamily
Evidence at transcript level
Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Additional Detail Fields 6 fields
Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at transcript level
Sea anemone sodium channel inhibitory toxin family, Type I subfamily
Delta-actitoxin-Axm1c (Delta-AITX-Axm1c) (PCR1-2) (Toxin PCR1)
sea anemone