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Peptide record

TPDB32020

Neurotoxin Toxicity standard
41 amino acids
Basic Information
3D PDB MODEL
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TPDB32020
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 41-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
GVDKAGCRYMFGGCSVNDDCCPRLGCHSLFSYCAWDLTFSD
Physicochemical Analysis
C192H280N52O60S7
EQI
C
4501.07
4.45
4
5
14
-2
0.63
0.015
47.56
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
8855
196.73
14
Residue Composition
number
2
A
2
R
1
N
5
D
6
C
0
E
0
Q
5
G
1
H
0
I
3
L
1
K
1
M
3
F
1
P
4
S
1
T
1
W
2
Y
2
V
Amino Acid Distribution
A: 2 R: 2 N: 1 D: 5 C: 6 E: 0 Q: 0 G: 5 H: 1 I: 0 L: 3 K: 1 M: 1 F: 3 P: 1 S: 4 T: 1 W: 1 Y: 2 V: 2
Chemical Descriptors
41
C192H280N52O60S7
4501.07
4.45
-2
0.63
0.015
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Toxin that blocks vertebrate P/Q-type (Cav2.1/CACNA1A) and R-type (Cav2.3/CACNA1E) voltage-gated calcium channels. Also inhibits sodium channels (Nav) in bovine chromaffin cells by delaying sodium channel inactivation. {ECO:0000269|PubMed:11423396, ECO:0000269|PubMed:12954354, ECO:0000269|PubMed:9799496}.

Target

voltage-gated sodium channel (Nav) voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Hysterocrates gigas (Cameroon red baboon tarantula)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin Voltage-gated sodium channel impairing toxin
Toxin that blocks vertebrate P/Q-type (Cav2.1/CACNA1A) and R-type (Cav2.3/CACNA1E) voltage-gated calcium channels. Also inhibits sodium channels (Nav) in bovine chromaffin cells by delaying sodium channel inactivation..
Omega-theraphotoxin-Hg1a (Omega-TRTX-Hg1a) (Toxin SNX-482) (SNX482)
spider
Neurotoxin 10 (Hwtx-1) family, 56 (SNX-482) subfamily
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family, 56 (SNX-482) subfamily
Omega-theraphotoxin-Hg1a (Omega-TRTX-Hg1a) (Toxin SNX-482) (SNX482)
TISSUE SPECIFICITY: Expressed by the venom gland.
spider