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Peptide record

TPDB32006

Neurotoxin Toxicity standard
38 amino acids
Basic Information
3D PDB MODEL
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TPDB32006
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 38-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
GVEINVKCTGSHQCIKPCKDAGMRFGKCINRKCHCTPK
Physicochemical Analysis
C174H293N57O49S7
LWY
CK
4192.01
9.27
10
2
8
+6
11.74
-0.524
48.68
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
375
8.95
12
Residue Composition
number
1
A
2
R
2
N
1
D
6
C
1
E
1
Q
4
G
2
H
3
I
0
L
6
K
1
M
1
F
2
P
1
S
2
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 2 N: 2 D: 1 C: 6 E: 1 Q: 1 G: 4 H: 2 I: 3 L: 0 K: 6 M: 1 F: 1 P: 2 S: 1 T: 2 W: 0 Y: 0 V: 2
Chemical Descriptors
38
C174H293N57O49S7
4192.01
9.27
+6
11.74
-0.524
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Potent inhibitor of voltage-dependent potassium channels, with a preference for Kv1.3/KCNA3 versus Kv1.2/KCNA2. {ECO:0000269|PubMed:18804453}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Androctonus amoreuxi (African fattail scorpion) (Scorpio amoreuxi)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Potent inhibitor of voltage-dependent potassium channels, with a preference for Kv1.3/KCNA3 versus Kv1.2/KCNA2..
Potassium channel toxin alpha-KTx 3.12 (Kaliotoxin analog) (Aam-KTX)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 03 subfamily
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 03 subfamily
Potassium channel toxin alpha-KTx 3.12 (Kaliotoxin analog) (Aam-KTX)
TISSUE SPECIFICITY: Expressed by the venom gland.
scorpion