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Peptide record

TPDB31999

Neurotoxin Toxicity standard
48 amino acids
Basic Information
3D PDB MODEL
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TPDB31999
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 48-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
GVACRCDSDGPTSRGNTLTGTLWLTGGCPSGWHNCRGSGPFIGYCCKK
Physicochemical Analysis
C209H323N65O65S6
EQM
G
4978.62
8.31
6
2
10
+3
2.04
-0.362
40.62
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
12865
258.40
18
Residue Composition
number
1
A
3
R
2
N
2
D
6
C
0
E
0
Q
10
G
1
H
1
I
3
L
2
K
0
M
1
F
3
P
4
S
5
T
2
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 3 N: 2 D: 2 C: 6 E: 0 Q: 0 G: 10 H: 1 I: 1 L: 3 K: 2 M: 0 F: 1 P: 3 S: 4 T: 5 W: 2 Y: 1 V: 1
Chemical Descriptors
48
C209H323N65O65S6
4978.62
8.31
+3
2.04
-0.362
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds specifically to voltage-gated sodium channels (Nav) (site 3), thereby delaying their inactivation. This toxin has moderate activity on Nav1.1/SCN1A (EC(50)=about 300 nM) and Nav1.5/SCN5A (EC(50)=307.00 nM). It less potent on Nav1.4/SCN4A (EC(50)=820.84 nM), Nav1.6/SCN8A (EC(50)=about 900 nM), Nav1.2/SCN2A (EC(50)=1449.17 nM) and Nav1.3/SCN3A (EC(50)=1458.42 nM) (when measured as the increase in the slow component). {ECO:0000269|PubMed:15169781}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Bunodosoma caissarum (Sea anemone)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Binds specifically to voltage-gated sodium channels (Nav) (site 3), thereby delaying their inactivation. This toxin has moderate activity on Nav1.1/SCN1A (EC(50)=about 300 nM) and Nav1.5/SCN5A (EC(50)=307.00 nM).
Delta-actitoxin-Bcs1a (Delta-AITX-Bcs1a) (Bc-III) (Major neurotoxin BcIII)
sea anemone
Sea anemone sodium channel inhibitory toxin family, Type I subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Additional Detail Fields 6 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Sea anemone sodium channel inhibitory toxin family, Type I subfamily
Delta-actitoxin-Bcs1a (Delta-AITX-Bcs1a) (Bc-III) (Major neurotoxin BcIII)
sea anemone