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Peptide record

TPDB31996

Neurotoxin Toxicity standard
47 amino acids
Basic Information
3D PDB MODEL
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TPDB31996
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 47-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
GVACLCDSDGPNVRGNTLSGTIWLAGCPSGWHNCKAHGPTIGWCCKQ
Physicochemical Analysis
C207H317N63O62S6
EMFY
G
4872.54
7.65
5
2
13
+1
1.59
-0.121
60.21
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
16875
346.33
16
Residue Composition
number
3
A
1
R
3
N
2
D
6
C
0
E
1
Q
8
G
2
H
2
I
3
L
2
K
0
M
0
F
3
P
3
S
3
T
3
W
0
Y
2
V
Amino Acid Distribution
A: 3 R: 1 N: 3 D: 2 C: 6 E: 0 Q: 1 G: 8 H: 2 I: 2 L: 3 K: 2 M: 0 F: 0 P: 3 S: 3 T: 3 W: 3 Y: 0 V: 2
Chemical Descriptors
47
C207H317N63O62S6
4872.54
7.65
+1
1.59
-0.121
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds specifically to voltage-gated sodium channels (Nav), thereby delaying their inactivation. This toxin is active on a variety of voltage-gated sodium channels (Nav1.1/SCN1A, Nav1.2/SCN2A, Nav1.3/SCN3A, Nav1.4/SCN4A, Nav1.5/SCN5A and Nav1.6/SCN8A). {ECO:0000250|UniProtKB:P10454}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Anthopleura fuscoviridis (Sea anemone)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Binds specifically to voltage-gated sodium channels (Nav), thereby delaying their inactivation. This toxin is active on a variety of voltage-gated sodium channels (Nav1.1/SCN1A, Nav1.2/SCN2A, Nav1.3/SCN3A, Nav1.4/SCN4A, Nav1.5/SCN5A and Nav1.6/SCN8A)..
Delta-actitoxin-Afv1a (Delta-AITX-Afv1a) (Toxin AFT-I) (AFI)
sea anemone
Sea anemone sodium channel inhibitory toxin family, Type I subfamily
Evidence at protein level
Cardiotoxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Additional Detail Fields 6 fields
Cardiotoxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Sea anemone sodium channel inhibitory toxin family, Type I subfamily
Delta-actitoxin-Afv1a (Delta-AITX-Afv1a) (Toxin AFT-I) (AFI)
sea anemone