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Peptide record

TPDB31995

Neurotoxin Toxicity standard
47 amino acids
Basic Information
3D PDB MODEL
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TPDB31995
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 47-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
GVACLCDADGPSVSGNTLSGILWLAGCPSGWHNCKAHGPTIGWCCKK
Physicochemical Analysis
C206H317N59O60S6
REQMFY
G
4772.50
7.65
5
2
15
+1
0.03
0.157
70.64
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
16875
353.59
14
Residue Composition
number
4
A
0
R
2
N
2
D
6
C
0
E
0
Q
8
G
2
H
2
I
4
L
3
K
0
M
0
F
3
P
4
S
2
T
3
W
0
Y
2
V
Amino Acid Distribution
A: 4 R: 0 N: 2 D: 2 C: 6 E: 0 Q: 0 G: 8 H: 2 I: 2 L: 4 K: 3 M: 0 F: 0 P: 3 S: 4 T: 2 W: 3 Y: 0 V: 2
Chemical Descriptors
47
C206H317N59O60S6
4772.50
7.65
+1
0.03
0.157
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds specifically to voltage-gated sodium channels (Nav), thereby delaying their inactivation. This toxin is active on a variety of voltage-gated sodium channels (Nav1.1/SCN1A, Nav1.2/SCN2A, Nav1.3/SCN3A, Nav1.4/SCN4A, Nav1.5/SCN5A and Nav1.6/SCN8A). {ECO:0000250|UniProtKB:P10454}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Anthopleura xanthogrammica (Giant green sea anemone) (Actinia xanthogrammica)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Binds specifically to voltage-gated sodium channels (Nav), thereby delaying their inactivation. This toxin is active on a variety of voltage-gated sodium channels (Nav1.1/SCN1A, Nav1.2/SCN2A, Nav1.3/SCN3A, Nav1.4/SCN4A, Nav1.5/SCN5A and Nav1.6/SCN8A)..
Delta-actitoxin-Axm1e (Delta-AITX-Axm1e) (PCR2-5) (Toxin PCR2)
sea anemone
Sea anemone sodium channel inhibitory toxin family, Type I subfamily
Evidence at transcript level
Cardiotoxin Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Additional Detail Fields 6 fields
Cardiotoxin Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at transcript level
Sea anemone sodium channel inhibitory toxin family, Type I subfamily
Delta-actitoxin-Axm1e (Delta-AITX-Axm1e) (PCR2-5) (Toxin PCR2)
sea anemone