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Peptide record

TPDB31967

Neurotoxin Toxicity standard
47 amino acids
Basic Information
3D PDB MODEL
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TPDB31967
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 47-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
GTCAGQDKPCKETCDCCGERGQCVCEGPCICRQGYFWIAAYKLGNCK
Physicochemical Analysis
C210H328N62O66S10
HMS
C
5097.89
7.37
6
5
11
+1
8.63
-0.357
37.45
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
9105
178.60
18
Residue Composition
number
3
A
2
R
1
N
2
D
10
C
3
E
3
Q
7
G
0
H
2
I
1
L
4
K
0
M
1
F
2
P
0
S
2
T
1
W
2
Y
1
V
Amino Acid Distribution
A: 3 R: 2 N: 1 D: 2 C: 10 E: 3 Q: 3 G: 7 H: 0 I: 2 L: 1 K: 4 M: 0 F: 1 P: 2 S: 0 T: 2 W: 1 Y: 2 V: 1
Chemical Descriptors
47
C210H328N62O66S10
5097.89
7.37
+1
8.63
-0.357
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks voltage-gated sodium channels (Nav). Causes rapid general spastic paralysis and death when injected in mice at dose levels of less than 2 ug per mouse. {ECO:0000269|Ref.2}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Phoneutria reidyi (Brazilian Amazonian armed spider) (Ctenus reidyi)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Blocks voltage-gated sodium channels (Nav). Causes rapid general spastic paralysis and death when injected in mice at dose levels of less than 2 ug per mouse..
Delta-ctenitoxin-Pr2d (Delta-CNTX-Pr2d) (Neurotoxin PRTx32C1)
spider
Neurotoxin 03 (Tx2) family, 06 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:16278100, ECO:0000305}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 03 (Tx2) family, 06 subfamily
Delta-ctenitoxin-Pr2d (Delta-CNTX-Pr2d) (Neurotoxin PRTx32C1)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:16278100, ECO:0000305}.
spider