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Peptide record

TPDB31965

Antifungal Antiparasitic Toxicity standard
30 amino acids
Basic Information
3D PDB MODEL
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TPDB31965
Antifungal Antiparasitic Toxicity
Anti-infective peptides Toxicity and safety peptides
Antifungipept dbAMP 3.0 i2APP Peptipedia
standard
No
A 30-aa standard natural multi-activity (Antifungal, Antiparasitic, and Toxicity) peptide sequence curated from Antifungipept, dbAMP 3.0, i2APP, and other sources, with an available 3D structural model.
Sequence
GTLPCESCVWIPCISSVVGCSCKSKVCYKN
Physicochemical Analysis
C136H221N35O41S6
ARDQHMF
C
3194.82
8.02
3
1
9
+2
1.99
0.500
77.67
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
7365
230.53
14
Residue Composition
number
0
A
0
R
1
N
0
D
6
C
1
E
0
Q
2
G
0
H
2
I
1
L
3
K
0
M
0
F
2
P
5
S
1
T
1
W
1
Y
4
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 6 E: 1 Q: 0 G: 2 H: 0 I: 2 L: 1 K: 3 M: 0 F: 0 P: 2 S: 5 T: 1 W: 1 Y: 1 V: 4
Chemical Descriptors
30
C136H221N35O41S6
3194.82
8.02
+2
1.99
0.500
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
Toxicity
1.15 µM
Cytotoxic
Cytotoxicity: [Ref.29734037] Cytotoxicity against three cancer cell lines: MDA-MB-231 breast (IC50=1.15 µM), PC-3 prostate (IC50=1.05 µM), and OVCAR-3 ovarian (IC50=0.80 µM). Cytotoxicity against non-cancerous human dermal fibroblast cells was determined to be ∼3× less (3.13 µM) than cancer cell lines

Source & Reference

NA
DRAMP
Biochem J. 2006 Nov 15 400(1):1-12.##J Mol Biol. 1999 Dec 17 294(5):1327-1336.