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Peptide record

TPDB31954

Antiviral Toxicity standard
43 amino acids
Basic Information
3D PDB MODEL
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TPDB31954
Antiviral Toxicity
Anti-infective peptides Toxicity and safety peptides
AI4AVP dbAMP 3.0 DRAMP Peptipedia
standard
No
A 43-aa standard natural multi-activity (Antiviral and Toxicity) peptide sequence curated from AI4AVP, dbAMP 3.0, DRAMP, and other sources, with an available 3D structural model.
Sequence
GSPRTEYEACRVRCQVAEHGVERQRRCQQVCEKRLREREGRRE
Physicochemical Analysis
C209H355N83O67S4
NDIMFW
R
5230.87
9.23
13
8
8
+4
27.57
-1.628
40.70
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1740
33.26
11
Residue Composition
number
2
A
11
R
0
N
0
D
4
C
8
E
4
Q
3
G
1
H
0
I
1
L
1
K
0
M
0
F
1
P
1
S
1
T
0
W
1
Y
4
V
Amino Acid Distribution
A: 2 R: 11 N: 0 D: 0 C: 4 E: 8 Q: 4 G: 3 H: 1 I: 0 L: 1 K: 1 M: 0 F: 0 P: 1 S: 1 T: 1 W: 0 Y: 1 V: 4
Chemical Descriptors
43
C209H355N83O67S4
5230.87
9.23
+4
27.57
-1.628
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
Toxicity
235 µM
Cytotoxic
Cytotoxicity: [Ref.21195767] It exhibited ytotoxicity against uninfected C8166 cell line (IC50=235 µM). EC50 of the inhibition of syncytia formation and p24 antigen production were 50 µM (262 µg/ml) and 58 µM (306 µg/ml).

Source & Reference

NA
DRAMP
Biosci Biotechnol Biochem. 1997 Jun 61(6):984-988.##J Struct Biol. 2011 Apr 174(1):164-172.