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Peptide record

TPDB31933

Neurotoxin Toxicity standard
49 amino acids
Basic Information
3D PDB MODEL
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TPDB31933
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 49-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
GSCIESGKSCTHSRSMKNGLCCPKSRCNCRQIQHRHDYLGKRKYSCRCS
Physicochemical Analysis
C223H372N82O69S9
AFWV
CS
5594.45
9.57
14
2
7
+9
13.84
-1.051
31.84
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
3480
62.20
23
Residue Composition
number
0
A
6
R
2
N
1
D
8
C
1
E
2
Q
4
G
3
H
2
I
2
L
5
K
1
M
0
F
1
P
8
S
1
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 2 D: 1 C: 8 E: 1 Q: 2 G: 4 H: 3 I: 2 L: 2 K: 5 M: 1 F: 0 P: 1 S: 8 T: 1 W: 0 Y: 2 V: 0
Chemical Descriptors
49
C223H372N82O69S9
5594.45
9.57
+9
13.84
-1.051
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Potent and selective blocker of N-type voltage-gated calcium channels (Cav2.2/CACNA1B). Also blocks vertebrate Cav2.1/CACNA1A (P/Q-type) and Cav1.2/CACNA1C (L-type) channels at very high concentration (2 micromolar). {ECO:0000269|PubMed:7541240}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Segestria florentina (Tube-web spider) (Segestria gracilis)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Potent and selective blocker of N-type voltage-gated calcium channels (Cav2.2/CACNA1B). Also blocks vertebrate Cav2.1/CACNA1A (P/Q-type) and Cav1.2/CACNA1C (L-type) channels at very high concentration (2 micromolar)..
Omega-segestritoxin-Sf1a (Omega-SGTX-Sf1a) (Toxin SNX-325)
spider
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 6 fields
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Omega-segestritoxin-Sf1a (Omega-SGTX-Sf1a) (Toxin SNX-325)
TISSUE SPECIFICITY: Expressed by the venom gland.
spider