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Peptide record

TPDB31909

Neurotoxin Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB31909
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 15-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
GRDAYIADSENCTYT
Physicochemical Analysis
C69H103N19O28S1
QHLKMFPWV
ADTY
1678.75
3.70
1
3
5
-2
3.36
-0.873
39.33
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
2980
177.51
7
Residue Composition
number
2
A
1
R
1
N
2
D
1
C
1
E
0
Q
1
G
0
H
1
I
0
L
0
K
0
M
0
F
0
P
1
S
2
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 2 R: 1 N: 1 D: 2 C: 1 E: 1 Q: 0 G: 1 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 0 S: 1 T: 2 W: 0 Y: 2 V: 0
Chemical Descriptors
15
C69H103N19O28S1
1678.75
3.70
-2
3.36
-0.873
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits tetrodotoxin-sensitive voltage-gated sodium channels (TTX-S Nav) in rat dorsal root ganglion (DRG) neurons in a concentration- and voltage-dependent manner. Lowers the activation threshold and produces negative shifting of TTX-S sodium current activation curve. Induces shifting of the steady-state inactivation curve to the left, delays the recovery of TTX-S I(Na) from inactivation. {ECO:0000269|PubMed:19199142}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Olivierus martensii (Manchurian scorpion) (Mesobuthus martensii)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Inhibits tetrodotoxin-sensitive voltage-gated sodium channels (TTX-S Nav) in rat dorsal root ganglion (DRG) neurons in a concentration- and voltage-dependent manner. Lowers the activation threshold and produces negative shifting of TTX-S sodium current activation curve.
Toxin BmKNJX11
scorpion
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family
Toxin BmKNJX11
TISSUE SPECIFICITY: Expressed by the venom gland.
scorpion