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Peptide record

TPDB31885

Neurotoxin Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB31885
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 14-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
GRCCHPACGKNYSC
Physicochemical Analysis
C58H91N21O18S4
DEQILMFTWV
C
1498.73
8.30
3
0
2
+2
1.71
-0.557
7.14
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1740
116.10
7
Residue Composition
number
1
A
1
R
1
N
0
D
4
C
0
E
0
Q
2
G
1
H
0
I
0
L
1
K
0
M
0
F
1
P
1
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 1 D: 0 C: 4 E: 0 Q: 0 G: 2 H: 1 I: 0 L: 0 K: 1 M: 0 F: 0 P: 1 S: 1 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
14
C58H91N21O18S4
1498.73
8.30
+2
1.71
-0.557
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them (PubMed:10529206). Specifically blocks mammalian nAChR at the alpha-1/delta binding site (PubMed:10529206). Shows very low potency in blocking the alpha-1/gamma binding site (PubMed:10529206). {ECO:0000269|PubMed:10529206}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus magus (Magical cone)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them (PubMed:10529206). Specifically blocks mammalian nAChR at the alpha-1/delta binding site (PubMed:10529206).
Alpha-conotoxin MI (Alpha-MI) (CtxMI) (M1)
cone snail
Conotoxin A superfamily
Evidence at protein level
Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:7149738}.
Additional Detail Fields 7 fields
Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Evidence at protein level
Conotoxin A superfamily
Alpha-conotoxin MI (Alpha-MI) (CtxMI) (M1)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:7149738}.
cone snail