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Peptide record

TPDB31877

Neurotoxin Toxicity standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB31877
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 22-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
GRCCEGPNGCSSRWCKDHARCC
Physicochemical Analysis
C92H146N36O30S6
QILMFTYV
C
2428.75
8.02
5
2
2
+2
5.33
-0.891
4.55
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5875
241.89
9
Residue Composition
number
1
A
3
R
1
N
1
D
6
C
1
E
0
Q
3
G
1
H
0
I
0
L
1
K
0
M
0
F
1
P
2
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 3 N: 1 D: 1 C: 6 E: 1 Q: 0 G: 3 H: 1 I: 0 L: 0 K: 1 M: 0 F: 0 P: 1 S: 2 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
22
C92H146N36O30S6
2428.75
8.02
+2
5.33
-0.891
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Mu-conotoxins block voltage-gated sodium channels (Nav). This synthetic toxin inhibits tetrodotoxin-resistant and -sensitive voltage-gated sodium channels. This block is very slowly reversible. Causes seizures and paralysis, when injected intracranially into mice.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus catus (Cat cone)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Mu-conotoxins block voltage-gated sodium channels (Nav). This synthetic toxin inhibits tetrodotoxin-resistant and -sensitive voltage-gated sodium channels.
Mu-conotoxin CIIIA
cone snail
Conotoxin M superfamily
Evidence at transcript level
Amidation Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 7 fields
Amidation Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at transcript level
Conotoxin M superfamily
Mu-conotoxin CIIIA
TISSUE SPECIFICITY: Expressed by the venom duct.
cone snail