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Peptide record

TPDB31875

Neurotoxin Toxicity standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB31875
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 22-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
GRCCDVPNACSGRWCRDHAQCC
Physicochemical Analysis
C93H146N36O30S6
EILKMFTY
C
2440.77
7.64
4
2
4
+1
3.89
-0.545
22.27
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5875
240.70
9
Residue Composition
number
2
A
3
R
1
N
2
D
6
C
0
E
1
Q
2
G
1
H
0
I
0
L
0
K
0
M
0
F
1
P
1
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 3 N: 1 D: 2 C: 6 E: 0 Q: 1 G: 2 H: 1 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 1 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
22
C93H146N36O30S6
2440.77
7.64
+1
3.89
-0.545
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Mu-conotoxins block voltage-gated sodium channels (Nav). This synthetic toxin moderately blocks rNav1.1/SCN1A, rNav1.2/SCN2A, rNav1.3/SCN3A, rNav1.4/SCN4A, rNav1.5/SCN5A, and mNav1.6/SCN8A (PubMed:21652775). This block is very slowly reversible (PubMed:16533055). Causes seizures when injected intracranially into mice. {ECO:0000269|PubMed:16533055, ECO:0000269|PubMed:21652775}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus consors (Singed cone)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Mu-conotoxins block voltage-gated sodium channels (Nav). This synthetic toxin moderately blocks rNav1.1/SCN1A, rNav1.2/SCN2A, rNav1.3/SCN3A, rNav1.4/SCN4A, rNav1.5/SCN5A, and mNav1.6/SCN8A (PubMed:21652775).
Mu-conotoxin CnIIIA
cone snail
Conotoxin M superfamily
Evidence at protein level
Amidation Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct. Has not been isolated from the crude venom. {ECO:0000269|PubMed:19457347}.
Additional Detail Fields 7 fields
Amidation Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Conotoxin M superfamily
Mu-conotoxin CnIIIA
TISSUE SPECIFICITY: Expressed by the venom duct. Has not been isolated from the crude venom. {ECO:0000269|PubMed:19457347}.
cone snail