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Peptide record

TPDB31858

Neurotoxin Toxicity standard
43 amino acids
Basic Information
3D PDB MODEL
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TPDB31858
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 43-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
GRDSCVNKSRCAKYGYYSQCEVCCKKAGHKGGTCDFFKCKCKV
Physicochemical Analysis
C201H319N61O59S8
ILMPW
CK
4790.60
8.94
11
3
10
+7
9.43
-0.653
24.88
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
4970
103.74
17
Residue Composition
number
2
A
2
R
1
N
2
D
8
C
1
E
1
Q
5
G
1
H
0
I
0
L
8
K
0
M
2
F
0
P
3
S
1
T
0
W
3
Y
3
V
Amino Acid Distribution
A: 2 R: 2 N: 1 D: 2 C: 8 E: 1 Q: 1 G: 5 H: 1 I: 0 L: 0 K: 8 M: 0 F: 2 P: 0 S: 3 T: 1 W: 0 Y: 3 V: 3
Chemical Descriptors
43
C201H319N61O59S8
4790.60
8.94
+7
9.43
-0.653
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks Kv11/ERG potassium channels (tested in MMQ lactotroph cells that contain the three ERG channels: rKv11.1/KCNH2/ERG1, rKv11.2/KCNH6/ERG2 and rKv11.3/KCNH7/ERG3). This toxin can be used to distinguish slow deactivating components (ERGS) from fast deactivating components (ERGF) currents, since it specifically blocks ERGS. {ECO:0000269|PubMed:11978818}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Centruroides noxius (Mexican scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Blocks Kv11/ERG potassium channels (tested in MMQ lactotroph cells that contain the three ERG channels: rKv11.1/KCNH2/ERG1, rKv11.2/KCNH6/ERG2 and rKv11.3/KCNH7/ERG3). This toxin can be used to distinguish slow deactivating components (ERGS) from fast deactivating components (ERGF) currents, since it specifically blocks ERGS..
Potassium channel toxin gamma-KTx 3.1 (CnErgTx2) (CnErg2) (Ergtoxin-2) (ErgTx2) (Ergtoxin-like protein)
scorpion
Ergtoxin family, Gamma-KTx 3 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Ergtoxin family, Gamma-KTx 3 subfamily
Potassium channel toxin gamma-KTx 3.1 (CnErgTx2) (CnErg2) (Ergtoxin-2) (ErgTx2) (Ergtoxin-like protein)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
scorpion