Back to search

Peptide record

TPDB31816

Neurotoxin Toxicity standard
46 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB31816
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 46-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
GPSFCKANGKPCSYHADCCNCCLSGICKPSTNVILPGCSTSSFFRI
Physicochemical Analysis
C204H319N57O62S8
EQMW
C
4818.60
8.10
5
1
12
+3
1.69
0.165
53.04
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1990
41.30
21
Residue Composition
number
2
A
1
R
3
N
1
D
8
C
0
E
0
Q
4
G
1
H
3
I
2
L
3
K
0
M
3
F
4
P
7
S
2
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 2 R: 1 N: 3 D: 1 C: 8 E: 0 Q: 0 G: 4 H: 1 I: 3 L: 2 K: 3 M: 0 F: 3 P: 4 S: 7 T: 2 W: 0 Y: 1 V: 1
Chemical Descriptors
46
C204H319N57O62S8
4818.60
8.10
+3
1.69
0.165
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Iota-conotoxins bind to voltage-gated sodium channels (Nav) and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels (By similarity). Produces excitatory symptoms when injected intracranially into mice and is lethal at higher doses. Exposure to frog cutaneous pectoris induces spontaneous and repetitive action potentials. This effect is slowly reversible. Natural peptide (with D-Phe) is active on nerve, but not on muscle. Synthetic peptide (with L-Phe) is not active on both nerve and muscle. {ECO:0000250}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus radiatus (Rayed cone)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Iota-conotoxins bind to voltage-gated sodium channels (Nav) and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels (By similarity). Produces excitatory symptoms when injected intracranially into mice and is lethal at higher doses.
Iota-conotoxin-like r11b (I-superfamily conotoxin R11.14)
cone snail
Conotoxin I1 superfamily
Evidence at protein level
D-amino acid Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 7 fields
D-amino acid Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Conotoxin I1 superfamily
Iota-conotoxin-like r11b (I-superfamily conotoxin R11.14)
TISSUE SPECIFICITY: Expressed by the venom duct.
cone snail