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Peptide record

TPDB31812

Neurotoxin Toxicity standard
46 amino acids
Basic Information
3D PDB MODEL
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TPDB31812
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 46-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
GPSFCKADEKPCEYHSDCCNCCLSGICAPSTNWILPGCSTSSFFKI
Physicochemical Analysis
C212H318N54O67S8
RQMV
C
4951.66
5.37
4
4
12
-1
3.80
0.009
46.74
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
7490
151.26
20
Residue Composition
number
2
A
0
R
2
N
2
D
8
C
2
E
0
Q
3
G
1
H
3
I
2
L
3
K
0
M
3
F
4
P
7
S
2
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 2 D: 2 C: 8 E: 2 Q: 0 G: 3 H: 1 I: 3 L: 2 K: 3 M: 0 F: 3 P: 4 S: 7 T: 2 W: 1 Y: 1 V: 0
Chemical Descriptors
46
C212H318N54O67S8
4951.66
5.37
-1
3.80
0.009
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Iota-conotoxins bind to voltage-gated sodium channels (Nav) and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels. Produces general excitatory symptoms (By similarity). {ECO:0000250}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus radiatus (Rayed cone)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Iota-conotoxins bind to voltage-gated sodium channels (Nav) and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels. Produces general excitatory symptoms (By similarity)..
Iota-conotoxin-like R11.7
cone snail
Conotoxin I1 superfamily
Evidence at transcript level
D-amino acid Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 7 fields
D-amino acid Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at transcript level
Conotoxin I1 superfamily
Iota-conotoxin-like R11.7
TISSUE SPECIFICITY: Expressed by the venom duct.
cone snail