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Peptide record

TPDB31805

Conorfamide-Sr1 Neuropeptide Neurotoxin Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB31805
Conorfamide-Sr1
Neuropeptide Neurotoxin Toxicity
Toxicity and safety peptides Neuroactive peptides
Peptipedia NTxPred2 ToxinPred 3.0
standard
No
A 12-aa standard natural multi-activity (Neuropeptide, Neurotoxin, and Toxicity) peptide sequence curated from Peptipedia, NTxPred2, and ToxinPred 3.0, with an available 3D structural model.
Sequence
GPMGWVPVFYRF
Physicochemical Analysis
C73H98N16O14S1
ANDCEQHILKST
GFPV
1455.74
9.88
1
0
7
+1
-3.41
0.433
48.33
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
6990
480.17
1
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
0
L
0
K
1
M
2
F
2
P
0
S
0
T
1
W
1
Y
2
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 0 M: 1 F: 2 P: 2 S: 0 T: 0 W: 1 Y: 1 V: 2
Chemical Descriptors
12
C73H98N16O14S1
1455.74
9.88
+1
-3.41
0.433
Evidence Records 2 records
Evidence 1 Activity

Activity

Neuropeptide

Source & Reference

NA
NeuroPepV2

Other

Conus spurius
FMRFamide related peptide
Evidence 2 Activity

Activity

Neurotoxin
FUNCTION: This peptide activates mouse sensory neuron-specific G-protein coupled receptors MRGPRX1, but not human receptors (PubMed:30243794). In vivo, causes hyperactivity in mice when injected intracranially (PubMed:11738233). {ECO:0000269|PubMed:11738233, ECO:0000269|PubMed:30243794}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus spurius (Alphabet cone)
Neurotoxin G-protein coupled receptor impairing toxin
This peptide activates mouse sensory neuron-specific G-protein coupled receptors MRGPRX1, but not human receptors (PubMed:30243794). In vivo, causes hyperactivity in mice when injected intracranially (PubMed:11738233)..
Conorfamide-Sr1 (CNF-Sr1) (Cono-RFamide-Sr1)
cone snail
FARP (FMRFamide related peptide) family
Evidence at protein level
Amidation Direct protein sequencing G-protein coupled receptor impairing toxin Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:11738233}.
Additional Detail Fields 8 fields
FMRFamide related peptide
Amidation Direct protein sequencing G-protein coupled receptor impairing toxin Neurotoxin Secreted Toxin
Neurotoxin G-protein coupled receptor impairing toxin
Evidence at protein level
FARP (FMRFamide related peptide) family
Conorfamide-Sr1 (CNF-Sr1) (Cono-RFamide-Sr1)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:11738233}.
cone snail