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Peptide record

TPDB31804

Neurotoxin Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB31804
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 12-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
GPMEDPLEIIRI
Physicochemical Analysis
C61H103N15O19S1
ANCQHKFSTWYV
I
1382.64
3.83
1
3
5
-2
5.27
0.050
130.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
1
R
0
N
1
D
0
C
2
E
0
Q
1
G
0
H
3
I
1
L
0
K
1
M
0
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 1 C: 0 E: 2 Q: 0 G: 1 H: 0 I: 3 L: 1 K: 0 M: 1 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
12
C61H103N15O19S1
1382.64
3.83
-2
5.27
0.050
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: In contrast to other conorfamides, this peptide does not show activity on human and mouse sensory neuron-specific G-protein coupled receptors MRGPRX1 (PubMed:30243794). In vivo, it causes hyperactivity when injected intracranially into mice, and when injected into the foot of the fresh water snail P.paludosa (PubMed:18201803). It also causes paralysis when injected into the foot of the limpet P.opea (PubMed:18201803). Has no effect when injected below the rear part of the dorsal fin of the fish L.reticulatus (PubMed:18201803). {ECO:0000269|PubMed:18201803}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus spurius (Alphabet cone)
Neurotoxin
In contrast to other conorfamides, this peptide does not show activity on human and mouse sensory neuron-specific G-protein coupled receptors MRGPRX1 (PubMed:30243794). In vivo, it causes hyperactivity when injected intracranially into mice, and when injected into the foot of the fresh water snail P.paludosa (PubMed:18201803).
Conorfamide-Sr2 (CNF-Sr2) (Cono-RFamide-Sr2)
cone snail
FARP (FMRFamide related peptide) family
Evidence at protein level
Amidation Direct protein sequencing Gamma-carboxyglutamic acid Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:18201803}.
Additional Detail Fields 7 fields
Amidation Direct protein sequencing Gamma-carboxyglutamic acid Neurotoxin Secreted Toxin
Neurotoxin
Evidence at protein level
FARP (FMRFamide related peptide) family
Conorfamide-Sr2 (CNF-Sr2) (Cono-RFamide-Sr2)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:18201803}.
cone snail